Isolation and characterization of the mouse beta 2/neuroD gene promoter.

@article{Xu1998IsolationAC,
  title={Isolation and characterization of the mouse beta 2/neuroD gene promoter.},
  author={Wanhong Xu and Liam J. Murphy},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={247 3},
  pages={814-8}
}
Beta2/neuroD is a basic helix-loop-helix protein involved in differentiation of the endocrine pancreas and the central nervous system. A 2-kb fragment containing the 5' upstream region of the mouse beta2/neuroD gene was cloned and sequenced. The cloned fragment was tested for promoter activity in six cell lines. Strong promoter activity was apparent in the three pancreatic beta cell lines, beta-HC3, beta-HC9, and NIT-1, whereas weak activity was seen in NIH 3T3, Rat-1, and MCF-7 cell lines… CONTINUE READING