Isolation and characterization of the human tissue-type plasminogen activator structural gene including its 5' flanking region.

@article{Fisher1985IsolationAC,
  title={Isolation and characterization of the human tissue-type plasminogen activator structural gene including its 5' flanking region.},
  author={Robert J. Fisher and Edmund K Waller and Gianfranco i 77 Grygoryev Grossi and Diana Thompson and Richard Tizard and W. D. Schleuning},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 20},
  pages={11223-30}
}
mRNA specific for tissue type plasminogen activator (t-PA) is induced in HeLa cells by the tumor promoter phorbol myristate acetate (Waller, E.K., and Schleuning, W.D. (1985) J. Biol. Chem. 260, 6354-6360). To study the underlying mechanism, a cDNA library was constructed from phorbol myristate acetate stimulated HeLa cell mRNA and screened with two t-PA mRNA specific oligonucleotides (Edlund, T., Ny, T., Rånby, M., Heden, L.-O., Palm, G., Holmgren, E., and Josephson, S. (1983) Proc. Natl. Acad… CONTINUE READING

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