Isolation and characterization of the human MRE11 homologue.

  title={Isolation and characterization of the human MRE11 homologue.},
  author={John H.J Petrini and Marie E Walsh and C Dimare and X N Chen and Julie R. Korenberg and David T. Weaver},
  volume={29 1},
Mutation of the Saccharomyces cerevisiae RAD52 epistasis group gene, MRE11, blocks meiotic recombination, confers profound sensitivity to double-strand break damage, and has a hyperrecombinational phenotype in mitotic cells. We isolated a highly conserved human MRE11 homologue using a two-hybrid screen for DNA ligase I-interacting proteins. Human MRE11 shares approximately 50% identity with its yeast counterpart over the N-terminal half of the protein. MRE11 is expressed at the highest levels… CONTINUE READING

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