Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells.

@article{Crossley1996IsolationAC,
  title={Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells.},
  author={Merlin Crossley and Emma Whitelaw and Andrew Perkins and Gaynor J Williams and Yuko Fujiwara and Stuart H Orkin},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 4},
  pages={1695-705}
}
CACCC boxes are among the critical sequences present in regulatory elements of genes expressed in erythroid cells, as well as in selected other cell types. While an erythroid cell-specific CACCC-box-binding protein, EKLF, has been shown to be required in vivo for proper expression of the adult beta-globin gene, it is dispensable for the regulation of several other globin and nonglobin erythroid cell-expressed genes. In the work described here, we searched for additional CACCC-box transcription… CONTINUE READING

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