Isolation and characterization of rat CYP11B genes involved in late steps of mineralo- and glucocorticoid syntheses.

@article{Mukai1993IsolationAC,
  title={Isolation and characterization of rat CYP11B genes involved in late steps of mineralo- and glucocorticoid syntheses.},
  author={Kazumitsu Mukai and Masashi Imai and Hiroshi Shimada and Yuzuru Ishimura},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 12},
  pages={9130-7}
}
We isolated and characterized four forms of rat CYP11B genes, which were tentatively named CYP11B1, -B2, -B3, and -B4. Genomic Southern analyses indicated that the members of the rat CYP11B gene subfamily were confined to these four genes; among them, CYP11B1 and -B2 encoded steroid 11 beta-hydroxylase and aldosterone synthase, respectively, while CYP11B3 was a gene highly homologous to CYP11B1 without a known expression product. By being devoid of a region spanning two exons conserved in the… CONTINUE READING