Isolation and characterization of propoxyphenyl linked sildenafil and thiosildenafil analogues in health supplements.

@article{Kee2012IsolationAC,
  title={Isolation and characterization of propoxyphenyl linked sildenafil and thiosildenafil analogues in health supplements.},
  author={Chee Leong Kee and Xiaowei Ge and Hwee-ling Koh and M C Low},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2012},
  volume={70},
  pages={265-72}
}
Two new phosphodiesterase-5 inhibitors (PDE-5) which consist of one sildenafil analogue and one thiosildenafil analogue have been found in heath supplements. The structural properties of these analogues have been elucidated by NMR, high resolution MS, MS(2), UV and IR spectroscopy. The sildenafil analogue is very similar to aildenafil and the thiosildenafil analogue is similar to thioaildenafil, except the ethoxy group bonded to phenyl ring is replaced by a propoxy group. Hence, the sildenafil… CONTINUE READING