Isolation and characterization of primitive hematopoietic cells based on their position in the cell cycle.

@article{Srour2002IsolationAC,
  title={Isolation and characterization of primitive hematopoietic cells based on their position in the cell cycle.},
  author={Edward F Srour and Craig T. Jordan},
  journal={Methods in molecular medicine},
  year={2002},
  volume={63},
  pages={93-111}
}
Hematopoietic progenitor and stem cells are believed to lie dormant within the adult bone marrow microenvironment in a state characterized by both mitotic and metabolic quiescence. This state of cell-cycle quiescence has been the focus or target of many studies aimed at identifying cells with such mitotic properties for their eventual isolation and characterization. On the other hand, knowledge of the type, frequency, and primitive status of dividing cells in patients with malignant… CONTINUE READING

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