Isolation and characterization of osteoblast precursor cells from human bone marrow.

@article{Rickard1996IsolationAC,
  title={Isolation and characterization of osteoblast precursor cells from human bone marrow.},
  author={David J. Rickard and Moustapha Kassem and Theresa E. Hefferan and Gobinda Sarkar and Thomas C. Spelsberg and B. Lawrence Riggs},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1996},
  volume={11 3},
  pages={312-24}
}
Osteoblasts are derived from precursor cells present in low frequency in the stromal element of bone marrow. Because of the lack of a practical procedure to isolate osteoblast precursors from early cultures of plastic adherent cells from bone marrow, previous studies of marrow stromal cells have been made in confluent cultures of bone marrow when the osteoblast (OB) precursors are already differentiated. Also these studies utilized cultures containing mixed populations of cells including… CONTINUE READING
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