Isolation and characterization of novel cytotoxic saponins from Archidendron ellipticum.

Abstract

A series of new ester saponins, elliptosides A-J, has been isolated from the tropical plant Archidendron ellipticum (Leguminosae). These saponins were particularly cytotoxic to certain renal and melanoma cancer cell lines in the NCI's 60-cell line human tumor screen. The structures of elliptosides A, E, and F were elucidated by spectroscopic and chemical means. Elliptoside A showed in vivo antitumor activity against the LOX melanoma cell line.

Cite this paper

@article{Beutler1997IsolationAC, title={Isolation and characterization of novel cytotoxic saponins from Archidendron ellipticum.}, author={John A Beutler and Yoel Kashman and Lewis K. Pannell and John H. Cardellina and Marina R. Alexander and Michael S. Balaschak and T R Prather and Robert H. Shoemaker and Michael Boyd}, journal={Bioorganic & medicinal chemistry}, year={1997}, volume={5 8}, pages={1509-17} }