Isolation and characterization of multipotent skin-derived precursors from human skin.

@article{Toma2005IsolationAC,
  title={Isolation and characterization of multipotent skin-derived precursors from human skin.},
  author={Jean G. Toma and Ian A. McKenzie and Darius J. Bagli and F. D. Miller},
  journal={Stem cells},
  year={2005},
  volume={23 6},
  pages={727-37}
}
We have previously isolated, expanded, and characterized a multipotent precursor cell from mammalian dermis (termed skin-derived precursors [SKPs]) that can differentiate into both neural and mesodermal progeny. In this study, we report the isolation, expansion, and characterization of a similar precursor cell from neonatal human foreskin tissue. Like their rodent counterparts, human SKPs grew in suspension as spheres in the presence of the mitogens fibroblast growth factor 2 and epidermal… CONTINUE READING
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