Isolation and characterization of metastatic variants from human transitional cell carcinoma passaged by orthotopic implantation in athymic nude mice.

@article{Dinney1995IsolationAC,
  title={Isolation and characterization of metastatic variants from human transitional cell carcinoma passaged by orthotopic implantation in athymic nude mice.},
  author={Colin P. N. Dinney and Randi Fishbeck and Rakesh K. Singh and Beryl Y Eve and Sen Pathak and Nicola L Brown and B. Xie and Dominic Fan and Corazon D. Bucana and Isaiah Josh Fidler},
  journal={The Journal of urology},
  year={1995},
  volume={154 4},
  pages={1532-8}
}
PURPOSE These studies were designed to develop an orthotopic model for human bladder cancer and to isolate variant metastatic cell lines. MATERIALS AND METHODS The human bladder cancer cell line 253J was implanted into the muscular wall of the bladder of athymic nude mice. By in vivo recycling, we selected for 2 variant cell lines: 253J B-V, a bladder line isolated after 5 serial passages in the bladder, and 253J lung-IV, established from a lung tumor nodule that was recycled through the… CONTINUE READING

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