Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32.

Abstract

Mutations of the human Patched gene ( PTCH ) have been identified in individuals with the nevoid basal cell carcinoma syndrome (NBCCS) as well as in sporadic basal cell carcinomas and medulloblastomas. We have isolated a homologue of this tumour suppressor gene and localized it to the short arm of chromosome 1 (1p32.1-32.3). Patched 2 ( PTCH2 ) comprises 22… (More)

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@article{Smyth1999IsolationAC, title={Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32.}, author={Ian M Smyth and Meenakshi Narang and Tristan M. Evans and Claudia Heimann and Y. Nakamura and Georgia Chenevix-Trench and Thomas J. Pietsch and Carol Wicking and Brandon J. Wainwright}, journal={Human molecular genetics}, year={1999}, volume={8 2}, pages={291-7} }