Isolation and characterization of genetically engineered gallidermin and epidermin analogs.

  title={Isolation and characterization of genetically engineered gallidermin and epidermin analogs.},
  author={Birgit Ottenw{\"a}lder and Thomas Kupke and Stephan Brecht and Volker Gnau and J{\"o}rg W. Metzger and Giman Jung and Friedrich G{\"o}tz},
  journal={Applied and environmental microbiology},
  volume={61 11},
Gallidermin (Gdm) and epidermin (Epi) are highly homologous tetracyclic polypeptide antibiotics that are ribosomally synthesized by a Staphylococcus gallinarum strain and a Staphylococcus epidermidis strain, respectively. These antibiotics are secreted into media and are distinguished by the presence of the unusual amino acids lanthionine, 3-methyllanthionine, didehydrobutyrine, and S-(2-aminovinyl)-D-cysteine, which are formed by posttranslational modification. To study the substrate… CONTINUE READING


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