Isolation and characterization of four alternate c-erbB3 transcripts expressed in ovarian carcinoma-derived cell lines and normal human tissues

@article{Lee1998IsolationAC,
  title={Isolation and characterization of four alternate c-erbB3 transcripts expressed in ovarian carcinoma-derived cell lines and normal human tissues},
  author={Hakjoo Lee and Nita Jane Maihle},
  journal={Oncogene},
  year={1998},
  volume={16},
  pages={3243-3252}
}
ErbB-3 is a member of the epidermal growth factor receptor (EGFR/ErbB) family. In addition to the previously reported 6.2 kb full-length and 1.4 kb truncated c-erbB3 transcripts, we have observed a 1.7 kb c-erbB3 human transcript in Northern blots that specifically hybridizes to a probe of the extracellular domain of the receptor. Using 3′-RACE we have isolated four novel c-erbB3 cDNA clones of 1.6, 1.7, 2.1 and 2.3 kb from a human ovarian carcinoma-derived cell line. All four alternate… 
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It is demonstrated that expression of a truncated 100 kDa HER2 variant which encodes the extracellular domain of HER2 (HER-ECD) inhibits growth factor-mediated tumour cell proliferation suggesting an important role during the progression of human cancer.
erbB genes in the mouse uterus: cell-specific signaling by epidermal growth factor (EGF) family of growth factors during implantation.
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Autophosphorylation and immunoprecipitation studies provided evidence that uterine ErbB3 andErbB4 are biologically active and a comprehensive analysis of possible ligand-receptor signaling schemes for EGF-like ligands in implantation.
A naturally occurring secreted human ErbB3 receptor isoform inhibits heregulin-stimulated activation of ErbB2, ErbB3, and ErbB4.
A variety of receptor-mediated signaling pathways are controlled by both positive and negative extracellular regulators. In this study, we demonstrate that a naturally occurring secreted form of the
The ERBB3 receptor in cancer and cancer gene therapy
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A wide and centrally important role for ERBB3 in cancer is becoming increasingly apparent and small inhibitory RNA to ERBB2 or AKT is showing promise as a therapeutic approach to treatment of lung adenocarcinoma.
Novel ERBB4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma
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An RT‐PCR and sequencing strategy demonstrated the four ERBB4 JM variants to be encoded by two short exons containing the JMb and JMa sequences positioned in the order 5′ to 3′ and separated by a 121 bp intron.
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