Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90.

@article{Ohoka1998IsolationAC,
  title={Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90.},
  author={Y Ohoka and Yoshimi Takai},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={1998},
  volume={3 9},
  pages={603-12}
}
BACKGROUND Cortactin is a major phosphotyrosyl protein in pp60v-src-transformed chicken embryo cells. Cortactin binds to actin filament (F-actin) through a unique region which consists of six tandem 37 amino acid repeats, named cortactin repeats. Furthermore cortactin has one src homology 3 (SH3) domain. RESULTS In this study we have isolated two new isoforms of cortactin from the rat brain using a polymerase chain reaction (PCR) method, and have named the original cortactin as cortactin-A… CONTINUE READING
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