Isolation and characterization of broadly neutralizing human monoclonal antibodies to the e1 glycoprotein of hepatitis C virus.

@article{Meunier2008IsolationAC,
  title={Isolation and characterization of broadly neutralizing human monoclonal antibodies to the e1 glycoprotein of hepatitis C virus.},
  author={Jean-Christophe Meunier and Rodney S Russell and Vera Goossens and Sofie Priem and Hugo Walter and Erik Depla and Ann Union and Kristina N. Faulk and Jens Bukh and Suzanne U. Emerson and Robert H. Purcell},
  journal={Journal of virology},
  year={2008},
  volume={82 2},
  pages={
          966-73
        }
}
The relative importance of humoral and cellular immunity in the prevention or clearance of hepatitis C virus (HCV) infection is poorly understood. However, there is considerable evidence that neutralizing antibodies are involved in disease control. Here we describe the detailed analysis of human monoclonal antibodies (MAbs) directed against HCV glycoprotein E1, which may have the potential to control HCV infection. We have identified two MAbs that can strongly neutralize HCV-pseudotyped… CONTINUE READING
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