Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques

Abstract

Arylacetamide deacetylase (AADAC), a microsomal serine esterase, hydrolyzes drugs, such as flutamide, phenacetin and rifampicin. Because AADAC has not been fully investigated at molecular levels in cynomolgus macaques, the non-human primate species widely used in drug metabolism studies, cynomolgus AADAC cDNA was isolated and characterized. The deduced… (More)
DOI: 10.1292/jvms.14-0496

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