Isolation and characterization of anthramycin, a new antitumor antibiotic.

@article{Leimgruber1965IsolationAC,
  title={Isolation and characterization of anthramycin, a new antitumor antibiotic.},
  author={Willy Leimgruber and Vladimir Stefanovi{\'c} and Flore Schenker and Andrew E. Karr and J Berger},
  journal={Journal of the American Chemical Society},
  year={1965},
  volume={87 24},
  pages={
          5791-3
        }
}

Topical delivery of anthramycin I. Influence of neat solvents

Design, Synthesis, and Bioevaluation of a Novel Hybrid Molecular Pyrrolobenzodiazepine-Anthracenecarboxyimide as a Payload for Antibody-Drug Conjugate.

TLDR
It is demonstrated that T-PBA could be degraded through the lysosomal pathway to release the payload 37b3 after internalization, which showed a powerful killing effect on Her2-positive cancer cells in vitro.

A Patent Review on FDA‐Approved Antibody‐Drug Conjugates, Their Linkers and Drug Payloads

  • C. Chia
  • Biology, Chemistry
    ChemMedChem
  • 2022
TLDR
This review collates and discusses the patents protecting ADCs approved by the FDA up to 31 December 2021, with particular emphasis on their linker and cytotoxin payload technologies.

BIROn - Birkbeck Institutional Research Online DNA sequence-selective C8-linked

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The PBD-C8-conjugates tested in this study have a remarkable anti- 37 mycobacterial activity and can be further developed as DNA-targeted anti-tubercular drugs.

Microwave Irradiated Targeted Synthesis of Pyrrolobenzodiazepine Embrace 1,2,3-Triazole by Click Chemistry Synthetic Aspect and Evaluation of Anticancer and Antimicrobial Activity

Abstract A new series of pyrrolobenzodiazepine derivatives containing 1,2,3-triazoles moiety has been designed and developed via Cu(I)-catalyzed azide-alkyne cycloaddition reaction, click chemistry

Antibody–Drug Conjugates—A Tutorial Review

TLDR
This tutorial review explores and explains each ADC component (monoclonal antibody, linker moiety and cytotoxic payload) individually, highlights several EMA- and FDA-approved ADCs by way of case studies and offers a brief future perspective on the field of ADC research.

Biosynthetic Cyclization Catalysts for the Assembly of Peptide and Polyketide Natural Products

TLDR
This Review addresses the general cyclization mechanism of the TE domain, including oligomerization and the fungal C−C bond forming Claisen‐like cyclases (CLCs), and includes examples of cyclization catalysts acting within or at the end of a module.
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