Isolation and characterization of an oligodendrocyte precursor-derived B-cell epitope in multiple sclerosis.

@article{Archelos1998IsolationAC,
  title={Isolation and characterization of an oligodendrocyte precursor-derived B-cell epitope in multiple sclerosis.},
  author={Juan J. Archelos and Jacqueline Trotter and Stefano Carlo Previtali and Benedikt Weissbrich and Klaus Viktor Toyka and Hans-Peter Hartung},
  journal={Annals of neurology},
  year={1998},
  volume={43 1},
  pages={15-24}
}
In a search for possible central nervous system-specific autoantigens in multiple sclerosis (MS), a lambda-phage protein expression library was constructed from an oligodendrocyte-precursor cell line. The library was screened with pooled cerebrospinal fluid (CSF) from 54 patients with definite MS according to the criteria of Poser. Pooled CSF samples from 44 patients with other neurological diseases including bacterial meningitis and viral encephalitis were used as control. A total of 1,000,000… CONTINUE READING

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