Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells.

@article{Gospodarowicz1989IsolationAC,
  title={Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells.},
  author={Denis Gospodarowicz and J. A. Abraham and James Schilling},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 19},
  pages={7311-5}
}
A growth factor with specificity for vascular endothelial cells has been identified in conditioned medium of pituitary-derived folliculo stellate cells. This factor, named folliculo stellate-derived growth factor (FSdGF), was purified to homogeneity by a combination of heparin-Sepharose affinity chromatography, Bio-Gel P-60 exclusion chromatography, Mono S ion-exchange chromatography, and hydrophobic chromatography on a C4 reverse-phase HPLC column. FSdGF was characterized as a homodimer… CONTINUE READING

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