Isolation and characterization of a proline‐rich polypeptide from ovine colostrum

@article{Janusz1974IsolationAC,
  title={Isolation and characterization of a proline‐rich polypeptide from ovine colostrum},
  author={Maria Janusz and J{\'o}zef Lisowski and Frantisek Franek},
  journal={FEBS Letters},
  year={1974},
  volume={49}
}
Department of Immunochemistry, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 4 Chalubinski Str., 50 368 Wroclaw, Poland, and Czechoslovak Academy of Sciences, Institute of Organic Chemistry and Biochemistry, I6 610 &aha 6, Czechoslovakia 

Topics from this paper

Immunomodulatory activity of hexapeptides related to proline rich peptide from colostrum.
Twelve analogues of an immunomodulatory hexapeptide YVPGFP (I) derived from Proline rich peptide (from colostrum) have been synthesized with modifications at positions 2, 4 and 6. In MLR assay one ofExpand
Isolation and characterization of an immunomodulatory protein from bovine colostrum
TLDR
A colostral protein that augments natural killer (NK) cell activity was isolated from bovine colostrum and was soluble at a cold temperature, and precipitated by raising the temperature, reversible, and dependent on the concentration, pH, and ionic strength. Expand
Immunoregulatory properties of synthetic peptides, fragments of a proline-rich polypeptide (PRP) from ovine colostrum.
It has been previously found that a proline-rich polypeptide (PRP) isolated from ovine colostrum has a regulatory effect on the immune response. A nonapeptide fragmentExpand
Immunologically active nonapeptide fragment of a proline-rich polypeptide from ovine colostrum: amino acid sequence and immunoregulatory properties.
TLDR
The amino acid sequence of the nonapeptide indicated that PRP-3b is different from other known immunomodulators, and was compared with the NH2- nor the COOH-terminal fragment of PRP. Expand
Colostrum from different mammalian species-A rich source of colostrinin
TLDR
Colostrum, regardless of origin, appeared to be a rich source of CLN fractions that could be separated in gram quantities and Storage of colostrum in frozen or lyophilized form affected neither the quantity nor quality of the purified peptides compared with its preparation from fresh material. Expand
Towards an understanding of biological role of colostrinin peptides
TLDR
It is hoped that the beneficial use of colostrinin in Alzheimer’s Disease (AD), recently reported elsewhere, will revive interest in its clinical application for treatment and/or prophylaxis of many age-related disorders. Expand
The Alcohol-Induced Conformational Changes in Casein Micelles: A New Challenge for the Purification of Colostrinin
TLDR
A novel method for isolation and purification of the neuroprotective proline-rich polypeptides, also known as Colostrinin (CLN), which can be accomplished in less than a 48 h timeframe and preserves the structure and biological activity of the peptides. Expand
DETERMINAÇÃO DO POLIPEPTÍDEO RICO EM PROLINA (PRP): PESQUISA DE METODOLOGIA EM LATICÍNIOS PARA FUTURA UTILIZAÇÃO EM LEITE HUMANO
TLDR
This work had as objective to research a viable methodology to determine the presence of the proline amino acid in dairy products as milk, cheese and yoghurt, for future use in human milk. Expand
Colostrinine et utilisations de celle-ci
La presente invention concerne l'utilisation de la colostrinine comme medicament, particulierement pour le traitement de troubles chroniques du systeme nerveux central et du systeme immunitaire.
Colostral Proline-Rich Polypeptide Complexes. Comparative Study of the Antioxidant Properties, Cytokine-Inducing Activity, and Nitric Oxide Release of Preparations Produced by a Laboratory and a Large-Scale Method
Colostral proline-rich polypeptide complex (PRP) with immunoregulatory and procognitive activities shows beneficial effects in Alzheimer’s disease (AD). As the laboratory method of isolating PRP isExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 14 REFERENCES
Cuticlin: a noncollagen structural protein from Ascaris cuticle.
TLDR
A structural protein was isolated from the cuticle of Ascaris lumbricoides and studied by chemical analyses, electron microscopy, and X-ray diffraction, and the name “cuticlin” is proposed for this protein. Expand
Letter: Fragments of polyproline-like structure from a structural protein, cuticlin.
TLDR
Cuticlin is a proline-rich protein isolated from the cuticle of Ascaris lumbricoides and it is indicated that the fragments formed a conformation similar to poly-l-proline II in aqueous solution. Expand
The Structure of Copolymers of L-Proline with L-Glutamic Acid in Aqueous Solutions
Three copolymers of L-proline and L-glutamic acid were synthesized, and their equilibrium conformation in an aqueous solution was studied in relation to their composition. The molar ratios of theExpand
Colorimetric differentiation of hexosamines.
TLDR
The proposed colorimetric method has been found highly satisfactory for the analysis of hexosamines in preparations of mucopolysaccharides, mucoproteins, and articular cartilage and extends the usefulness of the Elson-Morgan reaction as a method of differentiating amino sugars. Expand
Colorimetric Method for Determination of Sugars and Related Substances
Simple sugars, oligosaccharides, polysaccharides, and their derivatives, including the methyl ethers with free or potentially free reducing groups, give an orangeyellow color w-hen treated withExpand
The thiobarbituric acid assay of sialic acids.
  • L. Warren
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 1959
TLDR
This chapter discusses the different aspects of thiobarbituric acid assay of sialic acid, which is suitable for measuring the release of bound sialoic acid by sialidase and hydrolysis of sIALic acid-containing material must be carried out for the measurement of total sialsic acids. Expand
Protein measurement with the Folin phenol reagent.
TLDR
Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein. Expand
Hoppe-Seyler’s z.Physiol
  • Analyt. Biocheml19,
  • 1973
Hoppe - Seyler ’ s z
  • Physiol . Chem .
  • 1968
...
1
2
...