Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoproteins 1 and 2: significantly increased expression in cancers of various tissues.

@article{Ozaki1998IsolationAC,
  title={Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoproteins 1 and 2: significantly increased expression in cancers of various tissues.},
  author={Ken-ichi Ozaki and Michio Nagata and Makato Suzuki and Tsutomu Fujiwara and Kazuki Ueda and Yasuo Miyoshi and Ei‐ichi Takahashi and Yusuke Nakamura},
  journal={Cancer research},
  year={1998},
  volume={58 16},
  pages={3499-503}
}
We have isolated and characterized a novel human lung-specific gene and observed its increased expression in cancers arising from various tissues. The cDNA, designated TSC403, contained an open reading frame of 1248 nucleotides encoding 416 amino acids; the deduced amino acid sequence showed significant similarities to lysosomal membrane glycoproteins (lamps) 1 and 2. We localized the gene to chromosomal band 3q27, a genomic region that is often amplified in human cancers of several tissue… CONTINUE READING