Isolation and characterization of a novel gene with differential expression in benign and malignant human breast tumours.

@article{Adams1992IsolationAC,
  title={Isolation and characterization of a novel gene with differential expression in benign and malignant human breast tumours.},
  author={Sean M. Adams and Nicholas R. Helps and M. G. Sharp and W. J. Brammar and Rosemary A. Walker and Jenny M. Varley},
  journal={Human molecular genetics},
  year={1992},
  volume={1 2},
  pages={91-6}
}
We report the identification of a novel cDNA representing an mRNA showing significantly higher levels of expression in benign breast lesions than in carcinomas. This cDNA was identified by differential screening of a cDNA library generated from a breast carcinoma, and shows consistently higher expression in fibroadenomas than in carcinomas. The expression in both benign and malignant tissues is highest in epithelial cells as determined by in situ hybridization to tissue sections. The nucleotide… CONTINUE READING