Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1).

@article{Toda1994IsolationAC,
  title={Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1).},
  author={Tosifusa Toda and Aritoshi Iida and Takashi Miwa and Yoshikazu Nakamura and Takashi Imai},
  journal={Human molecular genetics},
  year={1994},
  volume={3 3},
  pages={465-70}
}
To identify a gene responsible for multiple endocrine neoplasia type 1 (MEN1), we attempted to isolate potentially transcribable fragments from cosmid clones derived from a region on chromosome 11q13 where genetic linkage studies and analyses of loss of heterozygosity in MEN1-associated tumors have localized the MEN1 gene. By an exon-amplification method, we recovered three exon-like sequences from one of these clones, cCI11-367, and using these sequences as probes we were able to isolate new… CONTINUE READING

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