Isolation and characterization of a novel conus peptide with apparent antinociceptive activity.

@article{McIntosh2000IsolationAC,
  title={Isolation and characterization of a novel conus peptide with apparent antinociceptive activity.},
  author={John McIntosh and Grace Corpuz and Richard T. Layer and James E. Garrett and John D Wagstaff and Grzegorz Bulaj and A Vyazovkina and Doju Yoshikami and Lourdes J. Cruz and Baldomero M Olivera},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 42},
  pages={32391-7}
}
Cone snails are tropical marine mollusks that envenomate prey with a complex mixture of neuropharmacologically active compounds. We report the discovery and biochemical characterization of a structurally unique peptide isolated from the venom of Conus marmoreus. The new peptide, mr10a, potently increased withdrawal latency in a hot plate assay (a test of analgesia) at intrathecal doses that do not produce motor impairment as measured by rotarod test. The sequence of mr10a is NGVCCGYKLCHOC… CONTINUE READING

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