Isolation and characterization of a new immunomodulatory protein, ling zhi-8 (LZ-8), from Ganoderma lucidium.

@article{Kino1989IsolationAC,
  title={Isolation and characterization of a new immunomodulatory protein, ling zhi-8 (LZ-8), from Ganoderma lucidium.},
  author={Katsuhito Kino and Akimasa Yamashita and Kunihiro Yamaoka and Junji Watanabe and Seigo Tanaka and Kenton Ko and Kosuke Shimizu and Hajime Tsunoo},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 1},
  pages={472-8}
}
A novel protein with mitogenic activity in vitro and immunomodulating activity in vivo has been isolated from the mycelial extract of an Oriental medicinal fungus, ling zhi (Ganoderma lucidium). This protein was named ling zhi-8 (LZ-8) and its biochemical and immunological properties are described. LZ-8 was purified by two chromatographic systems, gel filtration and followed by ion-exchange, using an in vitro bioassay measuring blast-formation stimulatory activity toward mouse spleen… CONTINUE READING