Isolation and characterization of a monoamine oxidase inhibitor from tobacco leaves.

@article{Khalil2000IsolationAC,
  title={Isolation and characterization of a monoamine oxidase inhibitor from tobacco leaves.},
  author={Ashraf A Khalil and Salome Steyn and Neal Castagnoli},
  journal={Chemical research in toxicology},
  year={2000},
  volume={13 1},
  pages={31-5}
}
Recent positron emission tomography imaging studies have demonstrated a significant decrease in both monoamine oxidase A and B (MAO-A and MAO-B) activities in the brains of smokers. Normal levels of activity are observed in former smokers, suggesting the presence of one or more compounds in tobacco smoke that may inhibit these enzymes. In this paper, we report the results of efforts to identify compounds present in flue-cured tobacco leaves that inhibit MAO. The isolation procedure was guided… CONTINUE READING