Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene.

@article{Kwak1994IsolationAC,
  title={Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene.},
  author={Seung P. Kwak and D J Hakes and K J Martell and Jack E. Dixon},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 5},
  pages={3596-604}
}
Vaccinia phosphatase VH-1 and its mammalian counterparts, including protein-tyrosine phosphatases (PTPase) CL100 and VHR, constitute a novel subfamily of protein-tyrosine phosphatases that exhibits dual substrate specificity for phosphotyrosine- and phosphoserine/threonine-containing substrates. The expression of human VH-1-like PTPase CL100 is rapidly inducible by mitogen stimulation and oxidative stress, suggesting that this gene is transcriptionally regulated. In order to study the mechanism… CONTINUE READING

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