Isolation and characterization of a cytotoxic metabolite of Talaromyces bacillosporus

  title={Isolation and characterization of a cytotoxic metabolite of Talaromyces bacillosporus},
  author={Kenji Ishii and T Itoh and K. Kobayashi and Y Horie and Yoshio Ueno},
  journal={Applied and Environmental Microbiology},
  pages={941 - 943}
  • K. Ishii, T. Itoh, Y. Ueno
  • Published 1 March 1995
  • Biology, Chemistry
  • Applied and Environmental Microbiology
A cytotoxic metabolite, talarotoxin, was isolated from a fungus, Talaromyces bacillosporus IFO 8397, cultured on rice. The structure of the toxin was elucidated and found to contain a pyrrolizidinedione connected with a trans delta 1-octalin through a conjugated triene. 
Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii.
Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans, which displayed potent in vitro antifungal activity.
Traminines A and B, produced by Fusarium concentricum, inhibit oxidative phosphorylation in Saccharomyces cerevisiae mitochondria
Two new tetramic acid derivatives, traminines A and B, isolated from a culture broth of Fusarium concentricum FKI-7550 by bioassay-guided fractionation strongly suggest that they target mitochondrial machineries presiding over ATP production via oxidative phosphorylation.
Polyphasic taxonomy of the genus Talaromyces
Bioinspired Synthesis of (-)-PF-1018.
The synthesis of the tetramic acid PF-1018 is reported through an 8p electrocyclization, the product of which is immediately intercepted by a Diels-Alder cycloaddition, the success of which was critically dependent on the substitution pattern of the starting polyene and could be rationalized through DFD calculations.
Investigation of Filamentous Fungi Producing Safe, Functional Water-Soluble Pigments
Abstract The production of water-soluble pigments by fungal strains indigenous to South Korea was investigated to find those that are highly productive in submerged culture. Among 113 candidates, 34


Isolation and structures of oxaphenalenone dimers from Talaromyces bacillosporus.
Three new oxaphenalenone dimers, bacillosporins A-C, and one known xanthone carboxylic acid, pinselin, were isolated from a fungus, Talaromyces bacillosporus. Bacillosporin A (1) is an acetyl
Solaniol, a toxic metabolite of Fusarium solani.
Fusarium solani M-1-1 isolated from moldy bean hulls produces T-2 toxin, diacetoxyscirpenol, and a new toxic trichothecene, solaniol, in Czapek-Dox-peptone medium.
Isolation and characterization of two new trichothecenes from Fusarium sporotrichioides strain M-1-1
  • K. Ishii, Y. Ueno
  • Chemistry, Biology
    Applied and environmental microbiology
  • 1982
This article corrects the article on p. 542 in vol.
PF1018, a novel insecticidal compound produced by Humicola sp.
A new insecticidal compound PF1018 was isolated from the culture broth of Humicola sp. It exhibited insecticidal activity against a wide range of critical pest species. The structure of PF1018 was
Natural products from microorganisms.
The pharmacologically active natural products provide previously unrecognized structures as tools for fundamental research programs, as well as offering the possibility of direct use in medicine or in industrial processes.
A modified method of mixed lymphocyte reaction: establishment of the assay system and its application to extracts of fungal cultures.
A modified mixed lymphocyte reaction (MLR) assay was developed and can distinguish immunosuppressors from cytotoxic agents, and the highest response was observed with the combination of splenocytes of C3H/He mice as a stimulator and those of C57BL/6 as a responder.
Philosophy of new drug discovery.
  • S. Ōmura
  • Chemistry
    Microbiological reviews
  • 1986
It is a great honor for me to have been chosen as the recipient of the Hoechst-Roussel Award and it gives me great pleasure to have this opportunity to publish my point of view about the authors' research work and the discovery of new antibiotics and bioactive compounds.
Bioactive microbial products: focus upon mechanism of action.
Inhibitors of Cellular Proliferation, Receptor Antagonists, and Other Inhibitors are listed.