Isolation and characterization of a GnRH-like peptide from Octopus vulgaris.

@article{Iwakoshi2002IsolationAC,
  title={Isolation and characterization of a GnRH-like peptide from Octopus vulgaris.},
  author={Eiko Iwakoshi and Kyoko Takuwa-Kuroda and Yuko Fujisawa and Miki Hisada and Kazuyoshi Ukena and Kazuyoshi Tsutsui and Hiroyuki Minakata},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={291 5},
  pages={1187-93}
}
Gonadotropin-releasing hormone (GnRH) is the key peptide in the hypothalamo-hypophysial-gonadal axis, the core of regulation of reproduction in vertebrates. In this study, an octopus peptide with structural features similar to vertebrate GnRHs was isolated from brains of Octopus vulgaris. This peptide showed luteinizing hormone-releasing activity in quail anterior pituitary cells. A cDNA encoding the precursor protein was cloned. The RT-PCR transcripts were expressed in the supraesophageal and… CONTINUE READING

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