Isolation and characterization of SGE1: a yeast gene that partially suppresses the gal11 mutation in multiple copies.

@article{Amakasu1993IsolationAC,
  title={Isolation and characterization of SGE1: a yeast gene that partially suppresses the gal11 mutation in multiple copies.},
  author={H Amakasu and Yasuhiro Suzuki and Masafumi Nishizawa and Toshio Fukasawa},
  journal={Genetics},
  year={1993},
  volume={134 3},
  pages={675-83}
}
Recessive mutations of GAL11 in Saccharomyces cerevisiae cause pleiotropic defects that include weak fermentation of galactose, alpha-specific sterility and slow growth on nonfermentable carbon sources. Recent experiments suggest that Gal11P functions as a "co-activator" that links transcriptional activators, such as Gal4p and Grf1p/Rap1p/Tuf1p, with the basic transcription machinery. In the present experiments we isolated a gene, SGE1, that suppresses gal11 for growth on ethidium bromide… CONTINUE READING