Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase.

  title={Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase.},
  author={Douglas A Fisher and Jeffrey F Smith and Joann S. Pillar and Suzanne St Denis and Jeffrey B. Cheng},
  journal={Biochemical and biophysical research communications},
  volume={246 3},
As part of our efforts to understand the regulation of intracellular cAMP and to generate new targets for pharmacological intervention, we have cloned and characterized the first isozyme in a new family of cyclic nucleotide phosphodiesterases, PDE8A. PDE8A is most similar to PDE4 (38.5% amino acid identity in the catalytic domain), but is clearly not a member of any of the seven known PDE families. We report the cloning of human cDNA encoding the C-terminal 713 amino acids of the protein… CONTINUE READING
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