Isolation and characterization of Myrianthus holstii lectin, a potent HIV-1 inhibitory protein from the plant Myrianthus holstii(1).

@article{Charan2000IsolationAC,
  title={Isolation and characterization of Myrianthus holstii lectin, a potent HIV-1 inhibitory protein from the plant Myrianthus holstii(1).},
  author={Romila D. Charan and Murray H. G. Munro and Barry R O'Keefe and Sowder RCII and Tawnya Carlene McKee and Michael J. Currens and Lewis K. Pannell and Michael R. Boyd},
  journal={Journal of natural products},
  year={2000},
  volume={63 8},
  pages={1170-4}
}
Aqueous extracts from the African plant Myrianthus holstii potently inhibited the infection of the T-lymphoblastoid cell line, CEM-SS, by human immunodeficiency virus-1(RF) (HIV-1(RF)). The active constituent, M. holstii lectin (MHL), was purified by LH-20 column chromatography and reversed phase HPLC. MHL, a 9284-Da cysteine-rich protein, was characterized by amino acid analysis, N-terminal sequencing, ESIMS, and matrix-assisted laser-desorption ionization-time-of-flight mass spectrometry… CONTINUE READING
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