Isolation and characterization of Escherichia coli mutants exhibiting altered response to thymol.

@article{Shapira2007IsolationAC,
  title={Isolation and characterization of Escherichia coli mutants exhibiting altered response to thymol.},
  author={Roni Shapira and Efrat Mimran},
  journal={Microbial drug resistance},
  year={2007},
  volume={13 3},
  pages={157-65}
}
The antimicrobial mode of action of the plant essential oil thymol was studied with Escherichia coli. Random transposon-insertion mutants were screened for altered response to thymol. Of four mutants showing more sensitivity, three were found in rfaQ, whose product is involved in lipopolysaccharide biosynthesis, and the fourth in the quorum-sensing gene qseC. Mutants showing more resistance had mutations in genes whose products are involved in the degradation of short-lived regulatory and… CONTINUE READING
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