Isolation and characterization of DUSP11, a novel p53 target gene.

  title={Isolation and characterization of DUSP11, a novel p53 target gene.},
  author={Greta Caprara and Raffaella Zamponi and Marina Melixetian and Kristian Helin},
  journal={Journal of cellular and molecular medicine},
  volume={13 8B},
p53 regulates the expression of genes involved in cell cycle control, apoptosis and DNA damage repair. Here we demonstrate that DUSP11 (dual specificity phosphatase 11), a member of the protein tyrosine phosphatase family that binds to RNA-RNP complexes and RNA splicing factors, is a p53 target gene. Consistent with this, the expression of DUSP11 is induced in a p53-dependent manner after treatment with DNA damaging agents. Chromatin immunoprecipitation analysis showed that p53 binds to 2… CONTINUE READING
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