Isolation and characterization of AaWRKY1, an Artemisia annua transcription factor that regulates the amorpha-4,11-diene synthase gene, a key gene of artemisinin biosynthesis.

@article{Ma2009IsolationAC,
  title={Isolation and characterization of AaWRKY1, an Artemisia annua transcription factor that regulates the amorpha-4,11-diene synthase gene, a key gene of artemisinin biosynthesis.},
  author={Dongming Ma and Gaobin Pu and Caiyan Lei and Lanqing Ma and Huahong Wang and Yanwu Guo and Jianlin Chen and Zhigao Du and Hong Wang and Guofeng Li and Hechun Ye and Benye Liu},
  journal={Plant & cell physiology},
  year={2009},
  volume={50 12},
  pages={2146-61}
}
Amorpha-4,11-diene synthase (ADS) of Artemisia annua catalyzes the conversion of farnesyl diphosphate into amorpha-4,11-diene, the first committed step in the biosynthesis of the antimalarial drug artemisinin. The promoters of ADS contain two reverse-oriented TTGACC W-box cis-acting elements, which are the proposed binding sites of WRKY transcription factors. A full-length cDNA (AaWRKY1) was isolated from a cDNA library of the glandular secretory trichomes (GSTs) in which artemisinin is… CONTINUE READING
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