Isolation and antihypertensive effect of angiotensin I-converting enzyme (ACE) inhibitory peptides from spinach Rubisco.

@article{Yang2003IsolationAA,
  title={Isolation and antihypertensive effect of angiotensin I-converting enzyme (ACE) inhibitory peptides from spinach Rubisco.},
  author={Yanjun Yang and Ewa D. Marczak and Megumi Yokoo and Hachiro Usui and Masaaki Yoshikawa},
  journal={Journal of agricultural and food chemistry},
  year={2003},
  volume={51 17},
  pages={
          4897-902
        }
}
Four new inhibitory peptides for angiotensin I-converting enzyme (ACE), that is, MRWRD, MRW, LRIPVA, and IAYKPAG, were isolated from the pepsin-pancreatin digest of spinach Rubisco with the use of HPLC. IC(50) values of individual peptides were 2.1, 0.6, 0.38, and 4.2 microM, respectively. MRW and MRWRD had an antihypertensive effect after oral administration to spontaneously hypertensive rats. Maximal reduction occurred 2 h after oral administration of MRW, whereas MRWRD showed maximal… 
Angiotensin-Converting Enzyme-Inhibitory Peptides Isolated from Pepsin Hydrolyzate of Apios americana Tuber and Their Hypotensive Effects in Spontaneously Hypertensive Rats
TLDR
Results suggest that YRLPNL, isolated from A. Americana, is the first report of a food peptide having ACE-inhibitory activity equal to that of pharmaceuticals.
Inhibition of Angiotensin-Converting Enzyme Activity by a Partially Purified Fraction of Gynura procumbens in Spontaneously Hypertensive Rats
TLDR
The results suggest that the hypotensive effect of G. procumbens may be due, in part, to the glycoconjugated or peptidal substances found in FA-I that exhibit an inhibitory effect on ACE.
Two angiotensin-converting enzyme-inhibitory peptides from almond protein and the protective action on vascular endothelial function.
TLDR
Results showed that the two potent ACE inhibitory peptides significantly regulated the release of nitric oxide and endothelin in HUVECs, suggesting that almond peptides have potential as an antihypertensive nutraceuticals or a functional food ingredient.
STRUCTURAL CHARACTERISTICS AND ANTIHYPERTENSIVE EFFECTS OF ANGIOTENSIN-I-CONVERTING ENZYME INHIBITORY PEPTIDES IN THE RENIN-ANGIOTENSIN AND KALLIKREIN KININ SYSTEMS
TLDR
The relationship between peptide amino acid sequence and inhibitory activity, in vivo studies of the active peptides and bioavailability must be studied before the peptides as antihypertensive agents can be claimed.
Antihypertensive activity of orally consumed ACE-I inhibitory peptides.
TLDR
This review attempts to explain the factors that affect the anti-hypertensive activity ofACE-I inhibitory peptides during oral consumption and highlights subsequent absorption of ACE-I inhibition peptides after gastrointestinal digestion.
...
...