Isolation and analysis of the gene encoding peripheral myelin protein zero.

  title={Isolation and analysis of the gene encoding peripheral myelin protein zero.},
  author={Greg Lemke and Elizabeth Lamar and John Patterson},
  volume={1 1},
We have isolated the gene encoding the Schwann cell glycoprotein P0, the major structural protein of the peripheral myelin sheath. In rats and mice, this gene is split into six exons distributed over 7 kb of DNA. The segregation of these exons is consistent with the functional segregation of the P0 protein into extracellular, membrane-spanning, and cytoplasmic domains. We find that the P0 extracellular domain is similar in structure to a single immunoglobulin variable region domain. In contrast… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 82 extracted citations


Publications referenced by this paper.
Showing 1-10 of 88 references

Genes and gene families related to immunoglobulin genes

  • C. Evans
  • Molecular Neurobiology, S. Heinemann, and J…
  • 1987
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…