Isolation and allelic polymorphism of cDNA clones and genomic clones of HLA-DP heavy and light chains.

@article{Ando1986IsolationAA,
  title={Isolation and allelic polymorphism of cDNA clones and genomic clones of HLA-DP heavy and light chains.},
  author={Asako Ando and Hidetoshi Inoko and Minoru Kimura and S. Ogata and Kimiyoshi Tsuji},
  journal={Human immunology},
  year={1986},
  volume={17 3},
  pages={
          355-67
        }
}
From a human cDNA library constructed from consanguineous HLA-homozygous cell line AKIBA (HLA-A24, Bw52, DR2, Dw12, Cp63 Cp63: a new DP type), cDNA clones encoding the heavy and light chains of an HLA-DP Cp63 alloantigen were isolated and analyzed by restriction enzyme mapping and nucleotide sequence determination. Allelic comparisons of DP alpha and DP beta cDNA sequences showed that the amino acid sequence of the DP alpha chain was less polymorphic than that of the DP beta chain. In the DP… CONTINUE READING