Isolation and absolute configuration of ent-Halimane diterpenoids from Hymenaea courbaril from the Suriname rain forest.

@article{AbdelKader2002IsolationAA,
  title={Isolation and absolute configuration of ent-Halimane diterpenoids from Hymenaea courbaril from the Suriname rain forest.},
  author={Maged Saad Abdel-Kader and John Joseph Berger and Carla Slebodnick and Jeannine M Hoch and Stan Malone and Jan H. Wisse and Marga C. M. Werkhoven and Steven W Mamber and David G I Kingston},
  journal={Journal of natural products},
  year={2002},
  volume={65 1},
  pages={
          11-5
        }
}
Bioactivity-directed fractionation of a methanol extract of Hymenaea courbaril afforded the three new diterpenoids (13R)-13-hydroxy-1(10),14-ent-halimadien-18-oic acid (1), (2S,13R)-2,13-dihydroxy-1(10),14-ent-halimadien-18-oic acid (2), and (13R)-2-oxo-13-hydroxy-1(10),14-ent-halimadien-18-oic acid (3). The configurations of these compounds were determined from X-ray crystallography of 1, circular dichroism of 2 and 3, and spectral studies of prepared derivatives. Compound 1 exhibited weak… CONTINUE READING
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