Isolation and Structural Determination of Enfumafungin, a Triterpene Glycoside Antifungal Agent That Is a Specific Inhibitor of Glucan Synthesis

  title={Isolation and Structural Determination of Enfumafungin, a Triterpene Glycoside Antifungal Agent That Is a Specific Inhibitor of Glucan Synthesis},
  author={Robert E. Schwartz and Scott K. Smith and J. C. Onishi and Maria S. Meinz and Myra Berman Kurtz and Robert A. Giacobbe and Kenneth E. Wilson and Jerrold M. Liesch and Deborah L. Zink and Wendy S. Horn and Sandra A. Morris and Angeles Cabello and Francisca Vicente},
  journal={Journal of the American Chemical Society},
Enfumafungin (1) is a hemiacetal, triterpene glycoside that was isolated from a fermentation of Hormonema sp. as a mixture of two interconverting forms. The primary structure of the major component of the mixture was determined as part of the mixture, mainly via NMR and comparison with hyalodendroside A (2), a related hemiacetal, triterpene glycoside that exists in a single form. The primary structure was confirmed, and the relative stereochemistry determined, based on a pair of methylacetal… 
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