Isolation and Characterization of a T Lymphocyte-Derived Differentiation Inducing Factor for the Myeloid Leukemic Cell

@inproceedings{Mangalasseril2005IsolationAC,
  title={Isolation and Characterization of a T Lymphocyte-Derived Differentiation Inducing Factor for the Myeloid Leukemic Cell},
  author={G. Mangalasseril and Sarngadharan and Theodore and R. and Breitman and Robert and C... and Gallo},
  year={2005}
}
  • G. Mangalasseril, Sarngadharan, +5 authors Gallo
  • Published 2005
Mitogen-stimulated mononuclear blood cells produce differentiation inducing factors (DIFs) for the promyelocytic cell line HL-60. We report that DIF is produced constitutively by a malignant T lymphocyte line HUT-102. DIF was purified 7.000-fold from HUT-i 02 conditioned media by utilizing ion-exchange chromatography with DEAE-Sepharose, gel chromatography… CONTINUE READING