Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China

@article{Guan2003IsolationAC,
  title={Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China},
  author={Yi Guan and B. J. Zheng and Y. Q. He and X. L. Liu and Zhi-xiong Zhuang and C. L. Cheung and S. W. Luo and P. H. Li and L. J. Zhang and Y. J. Guan and K. M. Butt and K. L. Wong and K. W. Chan and Wilina W. L. Lim and Kennedy F. Shortridge and Kwok Yung Yuen and J. S. Malik Peiris and L. L. M. Poon},
  journal={Science},
  year={2003},
  volume={302},
  pages={276 - 278}
}
A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in… Expand
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References

SHOWING 1-10 OF 22 REFERENCES
The Genome Sequence of the SARS-Associated Coronavirus
TLDR
The genome sequence reveals that the severe acute respiratory syndrome–associated coronavirus known as the Tor2 isolate is only moderately related to other known coronaviruses, andylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronavirs. Expand
A novel coronavirus associated with severe acute respiratory syndrome.
TLDR
A novel coronavirus is associated with this outbreak of severe acute respiratory syndrome, and the evidence indicates that this virus has an etiologic role in SARS. Expand
Koch's postulates fulfilled for SARS virus
TLDR
Understanding of the aetiology of SARS will expedite the development of diagnostic tests, antiviral therapies and vaccines, and may allow a more concise case definition for this emerging disease. Expand
Coronavirus as a possible cause of severe acute respiratory syndrome
TLDR
Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression. Expand
The World Health Organization.
TLDR
The data and methods used to produce the Version 2 estimates of burden of hypertensive disorders of pregnancy for the year 2000 are summarized and the long-term sequelae of both preeclampsia or eClampsia are not well evaluated. Expand
MEGA2: molecular evolutionary genetics analysis software
TLDR
MEGA2 vastly extends the capabilities of MEGA version 1 by facilitating analyses of large datasets, enabling creation and analyses of groups of sequences, and expanding the repertoire of statistical methods for molecular evolutionary studies. Expand
A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences
  • M. Kimura
  • Biology, Medicine
  • Journal of Molecular Evolution
  • 2005
TLDR
Some examples were worked out using reported globin sequences to show that synonymous substitutions occur at much higher rates than amino acid-altering substitutions in evolution. Expand
“Bioinformatics” 특집을 내면서
TLDR
Assessment of medical technology in the context of commercialization with Bioentrepreneur course, which addresses many issues unique to biomedical products. Expand
References and Notes
our experimentation could eventually be used to discredit our findings, should they happen not to agree with the original observations. It seems important that all experiments in the rapidlyExpand
China species information system
  • Science
  • 2003
...
1
2
3
...