Isolation and Characterization of Renal Erythropoietin-Producing Cells from Genetically Produced Anemia Mice

@inproceedings{Pan2011IsolationAC,
  title={Isolation and Characterization of Renal Erythropoietin-Producing Cells from Genetically Produced Anemia Mice},
  author={Xiaoqing Pan and Norio Suzuki and Ikuo Hirano and Shun Yamazaki and Naoko Minegishi and Masayuki Yamamoto},
  booktitle={PloS one},
  year={2011}
}
Understanding the nature of renal erythropoietin-producing cells (REPs) remains a central challenge for elucidating the mechanisms involved in hypoxia and/or anemia-induced erythropoietin (Epo) production in adult mammals. Previous studies have shown that REPs are renal peritubular cells, but further details are lacking. Here, we describe an approach to isolate and characterize REPs. We bred mice bearing an Epo gene allele to which green fluorescent protein (GFP) reporter cDNA was knocked-in… CONTINUE READING

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