Isolation and Characterization of Invasive and Noninvasive Variants of a Rat Bladder Tumor Cell Line

@inproceedings{Nishi1997IsolationAC,
  title={Isolation and Characterization of Invasive and Noninvasive Variants of a Rat Bladder Tumor Cell Line},
  author={Nozomu Nishi and Masashi Inui and Yukiko Kishi and Hiroshi Miyanaka and Fumio Wada},
  booktitle={Japanese journal of cancer research : Gann},
  year={1997}
}
We isolated, in vitro, spontaneous variants of the rat bladder tumor NBT-II cell line with a distinctive morphology. Of five sublines obtained, three (NBT-L1, L2a and L2b) exhibited an elongated shape and moderate to high invasive activity in vitro. The other two sublines (NBT-T1 and T2) formed tight colonies and exhibited very low or negligible invasive activity. The contents of mRNAs coding for E-cadherin and cadherin-associated molecules (alpha-catenin and beta-catenin) were not correlated… CONTINUE READING

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