Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea

Abstract

The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over… (More)
DOI: 10.3390/md13010444

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@inproceedings{Esposito2015IsolationAA, title={Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea}, author={Germana Esposito and Roberta Teta and Roberta Miceli and Luca Ceccarelli and Gerardo Della Sala and Rosa Camerlingo and Elena Irollo and Alfonso Mangoni and Giuseppe Antonio Pirozzi and Valeria Costantino}, booktitle={Marine drugs}, year={2015} }