Isolation and Antigenic Characterization of Lassa Virus

  title={Isolation and Antigenic Characterization of Lassa Virus},
  author={SONJA M. Buckley and Jordi Casals and Wilbur G. Downs},
LASSA fever as it was first noticed early in 1969 in three missionary nurses in Nigeria will be described by Frame et al.1. The disease later affected two laboratory workers at the Yale Arbovirus Research Unit (YARU) in New Haven. Two of the nurses and one of the laboratory workers died. 
Epidemiology and control of Lassa fever.
  • J. McCormick
  • Medicine
    Current topics in microbiology and immunology
  • 1987
The history of recognized human arenavirus infection in Africa began in 1969 with the mysterious death of two medical missionaries and the near-fatal illness of a third (Frame et al. 1970). An
50 Years of Lassa Fever Research.
  • R. Garry
  • Medicine, Biology
    Current topics in microbiology and immunology
  • 2020
This chapter reviews the key publications on Lassa fever research that appeared in the scientific literature at that time and over the ensuing decades.
Epidemiology and Control of Lassa fever
The Lassa Virus (an Arenavirus) is found in West Africa, where it sometimes a severe hemorrhage illness called Lassa fever. The antivirus drug ribavirin is effective, but only if administered early
The pathology of Lassa fever.
Arbovirus and other Virus Diseases in the Tropics Excluding the Viral Encephalitides
Many viruses have been identified as causes of human disease in tropical and subtropical regions and a few cause serious and fatal diseases.
Lassa fever in Benin: description of the 2014 and 2016 epidemics and genetic characterization of a new Lassa virus
Molecular investigations showed the viral genomes to be similar to that of the Togo strain, which is genetically very different from other known strains and confirms the existence of a new lineage of Lassa fever.
Lassa Virus
The intention of this review is to summarize in particular the recent literature on LassA virus and Lassa fever.
Arenaviridae: The Arenaviruses
Diseases: Lymphocytic choriomeningitis (LCM), Lassa fever, Argentine hemorrhagic fever (AHF), Bolivian hemorrhagic fever (BHF).
Lassa serology in natural populations of rodents and horizontal transmission.
The authors' data fit with a model implicating that most M. natalensis rodents become horizontally infected, clear the virus within a period significantly shorter than their life span, and develop antibodies, and suggests spillover infections in other rodent species.
A prospective study of the epidemiology and ecology of Lassa fever.
It is estimated that the ratio of fatalities to infection to be 1%-2%, a rate lower than estimates based on hospitalized cases, and eightfold rises in titer of antibody occurred in 1%-18% of the antibody-positive population, a result suggesting reinfection.


Tacaribe virus, a new agent isolated from Artibeus bats and mosquitoes in Trinidad, West Indies.
Isolation of a new entity, Tacaribe virus, from Artibeus bats and from mosquitoes, in Trinidad, is described and it is proposed for inclusion in the group of arthropod-borne viruses.
Propagation of Junin Virus, the Etiological Agent of Argentinian Hemorrhagic Fever, in HeLa Cell Cultures
  • N. Mettler, S. Buckley, J. Casals
  • Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1961
Junin virus, the etiological agent of Argentinian hemorrhagic fever has been propagated serially in HeLa cell cultures and evidence that the cytopathogenic agent was Junin virus was derived from fluorescent antibody studies and from neutralization tests with sera from animals immunized with the virus propagated in newborn mice.
Morphological and Cytochemical Studies on Lymphocytic Choriomeningitis Virus
The morphological evidence suggests that LCM should be considered as belonging to the presently unclassified group of lipoprotein-enveloped ribonucleic acid viruses.