Isolation, synthesis, and biological activity of aphrocallistin, an adenine-substituted bromotyramine metabolite from the Hexactinellida sponge Aphrocallistes beatrix.

@article{Wright2009IsolationSA,
  title={Isolation, synthesis, and biological activity of aphrocallistin, an adenine-substituted bromotyramine metabolite from the Hexactinellida sponge Aphrocallistes beatrix.},
  author={Amy E Wright and Gregory P. Roth and Jennifer K Hoffman and Daniela B. Divlianska and Diana Pechter and Susan H Sennett and Esther Amalia Guzm{\'a}n and Patricia A. Linley and Peter J. McCarthy and Tara Peterson Pitts and Shirley A. Pomponi and John K. Reed},
  journal={Journal of natural products},
  year={2009},
  volume={72 6},
  pages={1178-83}
}
A new adenine-substituted bromotyrosine-derived metabolite designated as aphrocallistin (1) has been isolated from the deep-water Hexactinellida sponge Aphrocallistes beatrix. Its structure was elucidated on the basis of spectral data and confirmed through a convergent, modular total synthetic route that is amenable toward future analogue preparation. Aphrocallistin inhibits the growth of a panel of human tumor cell lines with IC(50) values ranging from 7.5 to >100 microM and has been shown to… CONTINUE READING
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