Isolation, structure and antibacterial activity of pleosporone from a pleosporalean ascomycete discovered by using antisense strategy.
@article{Zhang2009IsolationSA, title={Isolation, structure and antibacterial activity of pleosporone from a pleosporalean ascomycete discovered by using antisense strategy.}, author={Chaowei Zhang and John G. Ondeyka and Deborah L. Zink and Ángela Basilio and Francisca Vicente and Javier Collado and Gonzalo Platas and Joann Huber and Karen Dorso and Mary R. Motyl and Kevin M. Byrne and Sheo B. Singh}, journal={Bioorganic \& medicinal chemistry}, year={2009}, volume={17 6}, pages={ 2162-6 } }
21 Citations
Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin
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Ascosetin inhibited bacterial growth with 2–16 μg ml−1 MIC values against Gram-positive strains including methicillin-resistant S. aureus and showed selectivity for bacterial growth inhibition compared with fungal but not mammalian cells.
Discovery of okilactomycin and congeners from Streptomyces scabrisporus by antisense differential sensitivity assay targeting ribosomal protein S4
- Biology, ChemistryThe Journal of Antibiotics
- 2009
Screening of microbial extracts using antisense-sensitized rpsD Staphylococcus aureus strain led to isolation of okilactomycin and four new congeners from Streptomyces scabrisporus, and all compounds showed a slight preferential inhibition of RNA synthesis over DNA and protein synthesis.
Isolation, structure elucidation, and biological activity of altersolanol P using Staphylococcus aureus fitness test based genome-wide screening.
- Biology, ChemistryJournal of natural products
- 2014
Altersolanol P exhibited Gram-positive antibacterial activity and inhibited the growth of Gram-negative Haemophilus influenzae and exhibited well aligned with the corresponding chemical shifts predicted by DFT calculations.
Isolation, structure elucidation, and antibacterial activity of methiosetin, a tetramic acid from a tropical sooty mold (Capnodium sp.).
- Chemistry, BiologyJournal of natural products
- 2012
In an antibiotic screening program for new drug leads with new modes of action using antisense Staphylococcus aureus Fitness Test screening, a new tetramic acid, methiosetin, is discovered from a tropical sooty mold, Capnodium sp.
Discovery and antibacterial activity of glabramycin A–C from Neosartorya glabra by an antisense strategy
- BiologyThe Journal of Antibiotics
- 2009
Glabramycin C showed strong antibiotics activity against Streptococcus pneumoniae and modest antibiotic activity against Staphylococcus aureus, and the isolation, structure, relative configuration and antibacterial activity, and plausible biogenesis of these compounds have been discussed.
Discovery and development of kibdelomycin, a new class of broad-spectrum antibiotics targeting the clinically proven bacterial type II topoisomerase.
- Biology, MedicineBioorganic & medicinal chemistry
- 2016
Discovery of kibdelomycin, a potent new class of bacterial type II topoisomerase inhibitor by chemical-genetic profiling in Staphylococcus aureus.
- BiologyChemistry & biology
- 2011
Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities.
- Biology, ChemistryBioorganic & medicinal chemistry letters
- 2012
Use of siRNA molecular beacons to detect and attenuate mycobacterial infection in macrophages.
- BiologyWorld journal of experimental medicine
- 2015
Antisense technology using synthetic siRNAs has been used in knocking down genes in bacteria and over the years this has evolved into a powerful tool for elucidating the roles of various genes mediating infectivity and survival in mycobacteria.
A review on different approaches to isolate antibiotic compounds from fungi
- Biology
- 2021
The revolutionizing impacts of the post-genomic era also aided these search in the form of various omics-based and biosynthetic approaches, which facilitate the invention of all-new compounds but contribute in the modification of existing compounds through which the compounds can serve as better drug candidates.
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