Isolation, primary structures and metal binding properties of neuronal growth inhibitory factor (GIF) from bovine and equine brain.

@article{Pountney1994IsolationPS,
  title={Isolation, primary structures and metal binding properties of neuronal growth inhibitory factor (GIF) from bovine and equine brain.},
  author={Dean L. Pountney and S M Fundel and Peter Faller and N E Birchler and Peter Hunziker and Milan Va{\vs}{\'a}k},
  journal={FEBS letters},
  year={1994},
  volume={345 2-3},
  pages={193-7}
}
Human neuronal growth inhibitory factor (GIF) impairs the survival of cultured neurons and is deficient in the brains of Alzheimer's disease victims. We have isolated and sequenced analogous proteins from bovine and equine brain. By comparing their primary structures with those of human, mouse and rat GIFs, a consensus GIF sequence was obtained. Although this exhibits ca. 65% similarity with primary structures of mammalian metallothioneins (MTs), some significant differences are expected in the… CONTINUE READING

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